Untangling Irregular Actin Cytoskeleton Architectures in Tomograms of the Cell with Struwwel Tracer
Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers, Slavica Jonić · 2023
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Description
Salim Sazzed and co-authors built a tracer for actin threads in cell tomograms in a 2023 paper. Actin forms a messy web that holds a cell's shape and drives its crawling. In cold electron scans the web runs in all directions amid noise and blind wedges, so hand tracing is slow and machine tracing is hard.
Their tool, Struwwel Tracer, grows short thread bits from seed points along the densest paths. A pruning map lets users judge which bits look real. Good bits then fuse step by step into long curved threads. On fake scans of a cell finger it scored high marks at all noise levels. On a real mouse cell scan its threads matched the known web well.
Catalog record
| CREATOR | Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers, Slavica Jonić |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |