The Development of Human Ex Vivo Models of Inflammatory Skin Conditions
Eddy Hsi Chun Wang, Rebecca Barresi-Thornton, Li-Chi Chen, Maryanne Makredes Senna, I-Chien Liao, Ying Chen, Qian Zheng, Charbel Bouez · 2023
Read The Development of Human Ex Vivo Models of Inflammatory Skin Conditions by Eddy Hsi Chun Wang, Rebecca Barresi-Thornton, Li-Chi Chen, Maryanne Makredes Senna, I-Chien Liao, Ying Chen, Qian Zheng, Charbel Bouez (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10743306.txt.
Description
Eddy Wang and co-authors build lab models of inflamed human skin from real skin samples in a 2023 paper. Animal models and rebuilt epidermis miss much of real skin's complexity, including its barrier fats and immune mix. The team instead takes living human skin kept outside the body and triggers it in different ways to mimic disease states.
One setup drives new blood vessel growth, one mimics harsh irritation, and one sustains immune cell attack. They track tissue damage, invading cells, signal proteins, and the skin's fat profile under each trigger. The irritant and chronic models showed deep disruption and strong immune influx, while the vessel model changed less. Such human-based models could test new skin drugs more faithfully than animal work.
Catalog record
| CREATOR | Eddy Hsi Chun Wang, Rebecca Barresi-Thornton, Li-Chi Chen, Maryanne Makredes Senna, I-Chien Liao, Ying Chen, Qian Zheng, Charbel Bouez |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |