Structural Characterization and Anti-Inflammatory Activity of Polysaccharides from Tremella fuciformis on Monosodium Urate-Stimulated RAW264.7 Macrophages
Wei Deng, Li Wu, Zheng Xiao, Yibin Li, Zhipeng Zheng, Shouhui Chen, Joe Vinson · 2023
Read Structural Characterization and Anti-Inflammatory Activity of Polysaccharides from Tremella fuciformis on Monosodium Urate-Stimulated RAW264.7 Macrophages by Wei Deng, Li Wu, Zheng Xiao, Yibin Li, Zhipeng Zheng, Shouhui Chen, Joe Vinson (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10743196.txt.
Description
Wei Deng and co-authors report a chemistry and cell study, published in 2023, on sugars from a snow fungus that calm inflammation. Tremella fuciformis is an edible mushroom whose polysaccharides are prized in food and cosmetics. The team first mapped what the sugars are made of, a mix of seven simple sugars led by mannose. They then tested them on immune cells provoked with urate crystals, the trigger of gout.
Treated cells released far less of three inflammatory messengers and showed lower oxidative damage, with a key protective enzyme rising. Gene sequencing traced the effect to two signaling pathways being damped. The authors present the fungal sugars as a foundation for new anti-inflammatory drugs aimed at crystal driven inflammation.
Catalog record
| CREATOR | Wei Deng, Li Wu, Zheng Xiao, Yibin Li, Zhipeng Zheng, Shouhui Chen, Joe Vinson |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |