PEPITEM Treatment Ameliorates EAE in Mice by Reducing CNS Inflammation, Leukocyte Infiltration, Demyelination, and Proinflammatory Cytokine Production
Mohammed Alassiri, Fahd Al Sufiani, Mohammed Aljohi, Asma Alanazi, Aiman Saud Alhazmi, Bahauddeen M Alrfaei, Hasan Alnakhli, Yasser A Alshawakir, Saleh M Alharby, Abdullah Y Almubarak, Mohammed Alasseiri, Nora Alorf, Mashan L Abdullah, David Naor · 2023
Read PEPITEM Treatment Ameliorates EAE in Mice by Reducing CNS Inflammation, Leukocyte Infiltration, Demyelination, and Proinflammatory Cytokine Production by Mohammed Alassiri, Fahd Al Sufiani, Mohammed Aljohi, Asma Alanazi, Aiman Saud Alhazmi, Bahauddeen M Alrfaei, Hasan Alnakhli, Yasser A Alshawakir, Saleh M Alharby, Abdullah Y Almubarak, Mohammed Alasseiri, Nora Alorf, Mashan L Abdullah, David Naor (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10743148.txt.
Description
Mohammed Alassiri and co-authors test an immune peptide in a mouse model of multiple sclerosis in a 2023 paper. The model, called EAE, mimics central nervous inflammation and myelin loss. PEPITEM is a peptide that blocks immune cells from crossing vessel walls. Female mice get it after the first signs of disease appear.
Treated mice show milder disease, the team reports. Fewer T cells enter the spinal cord, and levels of myelin and nerve proteins shift in spinal tissue. Two cytokine signals in blood and cord also fall. The authors suggest PEPITEM could calm inflammation in multiple sclerosis with fewer harms than synthetic drugs.
Catalog record
| CREATOR | Mohammed Alassiri, Fahd Al Sufiani, Mohammed Aljohi, Asma Alanazi, Aiman Saud Alhazmi, Bahauddeen M Alrfaei, Hasan Alnakhli, Yasser A Alshawakir, Saleh M Alharby, Abdullah Y Almubarak, Mohammed Alasseiri, Nora Alorf, Mashan L Abdullah, David Naor |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |