Evaluating the Efficacy of a Thermoresponsive Hydrogel for Delivering Anti-Collagen Antibodies to Reduce Posttraumatic Scarring in Orthopedic Tissues
Andrzej Steplewski, Jolanta Fertala, Lan Cheng, Mark L Wang, Michael Rivlin, Pedro Beredjiklian, Andrzej Fertala, Benjamin Gantenbein, Mohammad Jafar Abdekhodaie · 2023
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Description
Andrzej Steplewski and co-authors test a gel that carries a scar-fighting antibody, in a 2023 study on healing after injury. Thick scars in joints, tendons, and nerves cause pain and stiff movement. The team's antibody slows the growth of the fibers that form such scars, and it worked in an earlier rabbit study.
Here they load the antibody into a gel that thickens at body heat. They check how fast the drug leaves the gel, whether it stays stable, and whether it still binds its target after release. Early results suggest the gel could deliver the drug to injury sites. That would give surgeons a gentler option than cutting scar tissue out.
Catalog record
| CREATOR | Andrzej Steplewski, Jolanta Fertala, Lan Cheng, Mark L Wang, Michael Rivlin, Pedro Beredjiklian, Andrzej Fertala, Benjamin Gantenbein, Mohammad Jafar Abdekhodaie |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |