Hydrolysis of Oligodeoxyribonucleotides on the Microarray Surface and in Solution by Catalytic Anti-DNA Antibodies in Systemic Lupus Erythematosus
Tatiana S Novikova, Evgeny A Ermakov, Elena V Kostina, Alexander N Sinyakov, Alexey E Sizikov, Georgy A Nevinsky, Valentina N Buneva, Madhav Bhatia · 2023
Read Hydrolysis of Oligodeoxyribonucleotides on the Microarray Surface and in Solution by Catalytic Anti-DNA Antibodies in Systemic Lupus Erythematosus by Tatiana S Novikova, Evgeny A Ermakov, Elena V Kostina, Alexander N Sinyakov, Alexey E Sizikov, Georgy A Nevinsky, Valentina N Buneva, Madhav Bhatia (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10742339.txt.
Description
Novikova and co-authors study lupus antibodies that do not just bind DNA but cut it, in a 2023 paper. Anti-DNA antibodies are a hallmark of systemic lupus, and some of them act as enzymes that snip short DNA strands. The team compared antibodies from patients and healthy donors on short strands floating in solution and pinned to a microarray surface.
Patient antibodies cut the strands far more actively in both settings, though strands in solution were cut faster than tethered ones. Which strands got cut varied, hinting that patients raise antibodies against particular DNA motifs. The authors say surface effects must be kept in mind when DNA arrays are used to study the disease.
Catalog record
| CREATOR | Tatiana S Novikova, Evgeny A Ermakov, Elena V Kostina, Alexander N Sinyakov, Alexey E Sizikov, Georgy A Nevinsky, Valentina N Buneva, Madhav Bhatia |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |