Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway
Zi-Long Lu, Cong-Kuan Song, Shi-Shi Zou, Shi-Ze Pan, Kai Lai, Ning Li, Qing Geng, Peter C Hart, Yueqi Wang, Bing Zhou · 2023
Read Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway by Zi-Long Lu, Cong-Kuan Song, Shi-Shi Zou, Shi-Ze Pan, Kai Lai, Ning Li, Qing Geng, Peter C Hart, Yueqi Wang, Bing Zhou (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10742043.txt.
Description
Zi-Long Lu and co-authors tested whether a fruit acid can protect mouse lungs from the injury that follows a cut and return of blood flow, in a 2023 study. This injury strikes in many lung diseases and surgeries and can lead to low blood oxygen and organ failure. The acid, drawn from the peel of a fruit, is known to fight inflammation and oxidation.
Mice got low or high doses of the acid around the injury, and human vessel cells were put through a matching low-oxygen test. Treated lungs showed less damage, swelling, and inflammation. Markers of oxidative harm and iron-driven cell death fell, while a protective enzyme rose. The effect ran through a known oxygen-sensing pathway.
Catalog record
| CREATOR | Zi-Long Lu, Cong-Kuan Song, Shi-Shi Zou, Shi-Ze Pan, Kai Lai, Ning Li, Qing Geng, Peter C Hart, Yueqi Wang, Bing Zhou |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |