A Bioinformatics Toolkit for Next-Generation Sequencing in Clinical Oncology
Simon Cabello-Aguilar, Julie A. Vendrell, Jérôme Solassol · 2023
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Description
Simon Cabello-Aguilar, Julie Vendrell, and Jérôme Solassol present a 2023 review of the computing toolkit behind gene sequencing in cancer care. Modern sequencing reads tumor DNA at scale, and targeted drugs now match specific changes in that DNA. Software pipelines turn raw reads into findings a doctor can use: spotting variants, judging their meaning, and filtering noise. Each step needs the right tools.
The authors walk through the pipeline stages as used in clinics today. They give an updated list of the software needed at each stage, from alignment to interpretation. Their aim is to help researchers and clinicians run genetic analyses with more precision and speed. The review doubles as a practical reference for labs building or auditing a sequencing workflow. It stresses that good computing is now part of good cancer care.
Catalog record
| CREATOR | Simon Cabello-Aguilar, Julie A. Vendrell, Jérôme Solassol |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |