A Novel LncRNA MASCC1 Regulates the Progression and Metastasis of Head and Neck Squamous Cell Carcinoma by Sponging miR-195
Yujia Wang, Zhen Qin, Yiwen Chen, Yunfei Zheng, Lingfei Jia · 2023
Read A Novel LncRNA MASCC1 Regulates the Progression and Metastasis of Head and Neck Squamous Cell Carcinoma by Sponging miR-195 by Yujia Wang, Zhen Qin, Yiwen Chen, Yunfei Zheng, Lingfei Jia (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741893.txt.
Description
Yujia Wang and co-authors identify a long noncoding RNA that drives spread in head and neck cancer, in a 2023 paper. Long noncoding RNAs do not build proteins, but their levels shift in many cancers. Comparing metastatic and non-metastatic tumor samples, the team found one strongly raised in spreading tumors and named it MASCC1.
In sixty patient samples, high MASCC1 levels tracked with poor prognosis. Silencing it in cells slowed growth, movement, and invasion and raised cell death, and in mice it shrank tumors and cut spread to lymph nodes. The RNA works as a sponge for a small regulator, miR-195, freeing several growth genes from its control. The authors propose MASCC1 as a warning marker and drug target.
Catalog record
| CREATOR | Yujia Wang, Zhen Qin, Yiwen Chen, Yunfei Zheng, Lingfei Jia |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |