Chordoma: A Comprehensive Systematic Review of Clinical Trials
Sonja Chen, Ruben Ulloa, Justin Soffer, Roberto J Alcazar-Felix, Carl H Snyderman, Paul A Gardner, Vijay A Patel, Sean P Polster, Yasin Temel · 2023
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Description
Sonja Chen and co-authors present a systematic review, printed in 2023, mapping clinical trials for chordoma, a rare tumor of leftover embryonic tissue. Chordomas grow at the skull base, spine, and sacrum, hard against nerves and vessels, so even bold surgery often leaves disease that returns. The team searched four trial databases to chart what treatments are being tested.
One hundred and eight trials surfaced, fifty-one met the review's bar, and only fourteen were complete. Most tested drugs were borrowed from cancers sharing similar molecular pathways, with growing interest in combinations. Few finished trials had published results, a transparency gap the authors flag. They see promise in new biological targets and in studies of the disease's natural course.
Catalog record
| CREATOR | Sonja Chen, Ruben Ulloa, Justin Soffer, Roberto J Alcazar-Felix, Carl H Snyderman, Paul A Gardner, Vijay A Patel, Sean P Polster, Yasin Temel |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |