Ca2+ Signaling and Src Functions in Tumor Cells
Antonio Villalobo, Vladimir N Uversky · 2023
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Description
Antonio Villalobo reviews how calcium signals and the Src kinase family conspire inside tumor cells. Calcium ions choreograph much of cell life, and tumors routinely bend those signals. The Src kinases, including the cellular c-Src and its viral cousin v-Src, sit at crossroads of growth commands.
The review follows the messenger protein calmodulin, a calcium sensor that binds and tunes Src directly, and is itself phosphorylated by it. It also tracks calmodulin-guided enzymes and a phosphatase that push Src activity up or down. The tangled loops matter clinically: each node is a possible drug handle. The author closes by mapping which of these circuits might be worth targeting in human cancers.
Catalog record
| CREATOR | Antonio Villalobo, Vladimir N Uversky |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |