Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein
Dominique Bétemps, Jean-Noël Arsac, Simon Nicot, Dominique Canal, Habiba Tlili, Maxime Belondrade, Eric Morignat, Jérémy Verchère, Damien Gaillard, Lilian Bruyère-Ostells, Charly Mayran, Latifa Lakhdar, Daisy Bougard, Thierry Baron, François Ichas, John Woulfe · 2023
Read Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein by Dominique Bétemps, Jean-Noël Arsac, Simon Nicot, Dominique Canal, Habiba Tlili, Maxime Belondrade, Eric Morignat, Jérémy Verchère, Damien Gaillard, Lilian Bruyère-Ostells, Charly Mayran, Latifa Lakhdar, Daisy Bougard, Thierry Baron, François Ichas, John Woulfe (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741842.txt.
Description
Dominique Betemps and co-authors study, in a 2023 paper, how a disease-linked protein behaves in the brains of special mice. The protein, alpha-synuclein, folds wrongly in several human brain diseases, much like the prion protein in mad cow type illnesses.
The mice make a mutated human form of the protein and develop paralysis. Lab amplification of the folded protein made both human and mouse forms resist a strong enzyme, a hallmark of prion-like behavior. Injecting the amplified mouse protein into the mice cut the time to illness sharply. In sick brains, the resistant form gathered in rear regions where damage and a chemical tag on the protein were found.
Catalog record
| CREATOR | Dominique Bétemps, Jean-Noël Arsac, Simon Nicot, Dominique Canal, Habiba Tlili, Maxime Belondrade, Eric Morignat, Jérémy Verchère, Damien Gaillard, Lilian Bruyère-Ostells, Charly Mayran, Latifa Lakhdar, Daisy Bougard, Thierry Baron, François Ichas, John Woulfe |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |