Increased Thyroidal Activity on Routine FDG-PET/CT after Combination Immune Checkpoint Inhibition: Temporal Associations with Clinical and Biochemical Thyroiditis
Anna Galligan, Roslyn Wallace, Balasubramanian Krishnamurthy, Thomas W. H. Kay, Nirupa Sachithanandan, Cherie Chiang, Shahneen Sandhu, Rodney J. Hicks, Amir Iravani · 2023
Read Increased Thyroidal Activity on Routine FDG-PET/CT after Combination Immune Checkpoint Inhibition: Temporal Associations with Clinical and Biochemical Thyroiditis by Anna Galligan, Roslyn Wallace, Balasubramanian Krishnamurthy, Thomas W. H. Kay, Nirupa Sachithanandan, Cherie Chiang, Shahneen Sandhu, Rodney J. Hicks, Amir Iravani (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741830.txt.
Description
Anna Galligan and eight colleagues read thyroid signals on cancer scans to predict which patients on immune therapy will lose thyroid function, in a 2023 study. The scans, done to watch tumors, also catch inflamed glands as bright spots.
One hundred twenty-seven melanoma patients on combined immune therapy had scans reviewed blindly. A third developed thyroiditis by blood tests about three weeks into treatment. Scans, taken later, flagged thyroiditis with strong accuracy and near-perfect agreement between readers. Patients with bright thyroids on scan far more often progressed to full underactive thyroid than those without. The authors say the scan brightness marks a stronger, ongoing attack on the gland.
Catalog record
| CREATOR | Anna Galligan, Roslyn Wallace, Balasubramanian Krishnamurthy, Thomas W. H. Kay, Nirupa Sachithanandan, Cherie Chiang, Shahneen Sandhu, Rodney J. Hicks, Amir Iravani |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |