Corticotropin-Releasing Hormone: A Novel Stimulator of Somatolactin in Teleost Pituitary Cells
Ruixin Du, Xuetao Shi, Feng Chen, Li Wang, Hongwei Liang, Guangfu Hu · 2023
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Description
Ruixin Du and co-authors find a fresh job for a stress hormone in fish pituitary cells, in a 2023 study. The hormone, CRH, is best known for driving the body's stress response through the pituitary. Somatolactin is a fish-only hormone from the back part of the pituitary, and little was known about what calls it forth. Working with grass carp pituitary cells in dishes, the team found CRH strongly raised both forms of somatolactin.
Drug tests mapped three signal routes inside the cell that carry the hormone's call. A gene scan of liver cells then showed both somatolactin forms help govern fat use. The authors read this as a role for the hormone pair in the stress response, by steering how the body spends stored energy.
Catalog record
| CREATOR | Ruixin Du, Xuetao Shi, Feng Chen, Li Wang, Hongwei Liang, Guangfu Hu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |