Inhibition of DHODH Enhances Replication-Associated Genomic Instability and Promotes Sensitivity in Endometrial Cancer
Shengyuan Zhao, Aaliyah Francois, Dawit Kidane, Alexandros Georgakilas, Neville F Hacker · 2023
Read Inhibition of DHODH Enhances Replication-Associated Genomic Instability and Promotes Sensitivity in Endometrial Cancer by Shengyuan Zhao, Aaliyah Francois, Dawit Kidane, Alexandros Georgakilas, Neville F Hacker (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741824.txt.
Description
Shengyuan Zhao and co-authors target a metabolic enzyme in womb cancer in a 2023 study. The enzyme helps cells build DNA letters, and about 38 percent of these tumors overproduce it. Such tumors carry many mutations and unstable chromosomes. Blocking the enzyme, the team reasoned, may stress DNA copying further and push cancer cells over the edge.
High enzyme tumors also often carry faults in their DNA copying machines and grade as aggressive. In their tests, inhibition raised replication linked instability and made the cancer cells more sensitive. A drug that turns a tumor's own copying strain against it is an attractive strategy. The work nominates a patient group for such trials.
Catalog record
| CREATOR | Shengyuan Zhao, Aaliyah Francois, Dawit Kidane, Alexandros Georgakilas, Neville F Hacker |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |