Methylation Analysis of Urinary Sample in Non-Muscle-Invasive Bladder Carcinoma: Frequency and Management of Invalid Result
Francesco Pierconti, E D Rossi, V Fiorentino, A Bakacs, A Carlino, E Navarra, E Sacco, A Totaro, G Palermo, L M Larocca, M Martini, Panagiotis Vlachostergios, Ioannis Zachos · 2023
Read Methylation Analysis of Urinary Sample in Non-Muscle-Invasive Bladder Carcinoma: Frequency and Management of Invalid Result by Francesco Pierconti, E D Rossi, V Fiorentino, A Bakacs, A Carlino, E Navarra, E Sacco, A Totaro, G Palermo, L M Larocca, M Martini, Panagiotis Vlachostergios, Ioannis Zachos (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741688.txt.
Description
Pierconti and co-authors examine a practical annoyance with a urine test used to watch for bladder cancer returning. The test reads DNA methylation patterns and can flag high-grade recurrences, but in routine practice a share of tests come back invalid and must be repeated.
The study covered 782 patients with non-muscle-invasive high-grade bladder cancer, whose samples were either voided urine or bladder washings. Invalid results occurred at similar rates in both groups, so the collection method was not the culprit. The authors recommend pairing the methylation test with cytology and repeating an invalid test only when cytology also looks suspicious, saving patients needless repeat sampling.
Catalog record
| CREATOR | Francesco Pierconti, E D Rossi, V Fiorentino, A Bakacs, A Carlino, E Navarra, E Sacco, A Totaro, G Palermo, L M Larocca, M Martini, Panagiotis Vlachostergios, Ioannis Zachos |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |