Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids
Tolga Sever, Ender Berat Ellidokuz, Yasemin Basbinar, Hulya Ellidokuz, Ömer H. Yilmaz, Gizem Calibasi-Kocal · 2023
Read Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids by Tolga Sever, Ender Berat Ellidokuz, Yasemin Basbinar, Hulya Ellidokuz, Ömer H. Yilmaz, Gizem Calibasi-Kocal (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741617.txt.
Description
Tolga Sever and co-authors test whether a body fuel can make a bowel cancer drug bite harder. The fuel is a ketone the liver makes when food runs low. It can feed the burn cycle of the cell, which may push cancer cells to make more reactive oxygen species when the drug hits. Their 2023 study uses organoids, tiny gut growths that mimic the bowel of a patient in a dish.
Safe doses of the fuel plus the drug killed far more cancer cells than the drug alone. Energy marks in the cells shifted: sugar burning fell and deep burning rose. That shift fed cell death through the reactive species. A sleep hormone drug, tried as a shield, blocked the gain by guarding cells from the stress. The team sees a cheap add-on path for like drugs.
Catalog record
| CREATOR | Tolga Sever, Ender Berat Ellidokuz, Yasemin Basbinar, Hulya Ellidokuz, Ömer H. Yilmaz, Gizem Calibasi-Kocal |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |