Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation
Chiara Leotta, Leah Hernandez, Lubomira Tothova, Samsul Arefin, Paola Ciceri, Mario Gennaro Cozzolino, Peter Barany, Milan Chromek, Peter Stenvinkel, Karolina Kublickiene, Peter Droge · 2023
Read Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation by Chiara Leotta, Leah Hernandez, Lubomira Tothova, Samsul Arefin, Paola Ciceri, Mario Gennaro Cozzolino, Peter Barany, Milan Chromek, Peter Stenvinkel, Karolina Kublickiene, Peter Droge (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741614.txt.
Description
Chiara Leotta and co-authors track cell-free DNA around kidney transplant in this 2023 paper. DNA fragments float in blood and can signal organ stress or damage. One type comes from mitochondria and links to inflammation and early vessel aging.
Forty-four patients with kidney failure gave blood before transplant and two years after. Half had dialysis first, and half had conservative care instead. Mitochondrial DNA levels fell clearly after transplant, while other DNA types held steady. Dialysis patients started with higher total DNA levels than the other group. Patients with vessel scarring showed the sharpest post-transplant drops. The marker may help flag graft health without biopsy.
Catalog record
| CREATOR | Chiara Leotta, Leah Hernandez, Lubomira Tothova, Samsul Arefin, Paola Ciceri, Mario Gennaro Cozzolino, Peter Barany, Milan Chromek, Peter Stenvinkel, Karolina Kublickiene, Peter Droge |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |