Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion
Tian Liu, Liam Wetzel, Zexi Zhu, Pavan Kumaraguru, Viraj Gorthi, Yan Yan, Mohammed Zaheen Bukhari, Aizara Ermekbaeva, Hanna Jeon, Teresa R Kee, Jung-A Alexa Woo, David E Kang, Alexander Dityatev · 2023
Read Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion by Tian Liu, Liam Wetzel, Zexi Zhu, Pavan Kumaraguru, Viraj Gorthi, Yan Yan, Mohammed Zaheen Bukhari, Aizara Ermekbaeva, Hanna Jeon, Teresa R Kee, Jung-A Alexa Woo, David E Kang, Alexander Dityatev (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741529.txt.
Description
Tian Liu and co-authors show in a 2023 study how mutations in a mitochondrial protein jam the cell's cleanup of worn power plants. The protein, CHCHD10, is tied to inherited and sporadic forms of ALS and dementia. Its levels fall in patient brains, yet its grip on cleanup was unknown.
Two disease mutations slowed cleanup flow and blocked a key partner protein's arrival at damaged units. The healthy protein form did the reverse, boosting both measures in the models. The mutants freed an enzyme that trims the cleanup trigger, while the healthy form held that enzyme back. Human dementia brain tissue showed the same broken pathway marks. Blocking cleanup on purpose worsened harm in the models, sealing the causal read.
Catalog record
| CREATOR | Tian Liu, Liam Wetzel, Zexi Zhu, Pavan Kumaraguru, Viraj Gorthi, Yan Yan, Mohammed Zaheen Bukhari, Aizara Ermekbaeva, Hanna Jeon, Teresa R Kee, Jung-A Alexa Woo, David E Kang, Alexander Dityatev |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |