PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis
Jason A. Kirkbride, Garbo Young Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto · 2023
Read PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis by Jason A. Kirkbride, Garbo Young Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741526.txt.
Description
Jason Kirkbride and co-authors show that PHI-1, a built-in brake on a cell phosphatase, governs how long the Raf-1 kinase lasts in the cell. Raf-1 steers growth, death, and movement through the ERK path, and its level is set by more than its gene. PHI-1 is also flagged as a marker across cancers.
In their 2023 study, cutting PHI-1 in human cells sped growth and cut death, while ERK signaling soared. The surge traced to a rise in Raf-1 protein itself, not to more of its gene's message or to its usual partners. Added PHI-1 pushed Raf-1 down again. The brake thus guards the cell by holding a growth kinase on a short leash.
Catalog record
| CREATOR | Jason A. Kirkbride, Garbo Young Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |