Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts
Elizeth Lopes, Gisela Machado-Oliveira, Catarina Guerreiro Simões, Inês S Ferreira, Cristiano Ramos, José Ramalho, Maria I L Soares, Teresa M V D Pinho e Melo, Rosa Puertollano, André R A Marques, Otília V Vieira, Raj Kishore · 2023
Read Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts by Elizeth Lopes, Gisela Machado-Oliveira, Catarina Guerreiro Simões, Inês S Ferreira, Cristiano Ramos, José Ramalho, Maria I L Soares, Teresa M V D Pinho e Melo, Rosa Puertollano, André R A Marques, Otília V Vieira, Raj Kishore (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741512.txt.
Description
Elizeth Lopes and co-authors show how an oxidized fat harms cell recycling centers in a 2023 paper. The fat forms when stored cholesterol fats oxidize in artery walls. It appears in tissue from patients with heart and vessel disease. Fibroblasts help build artery plaques, so the team fed the fat to mouse fibroblasts.
Treated cells grew swollen recycling sacs stuffed with neutral fats near the nucleus. The cells did not build fresh sacs to compensate. Self cleaning slowed, likely through a growth signal switch, and cells began to die. The harm mirrors effects seen in other artery wall cells. This path may add one more way the fat drives plaque growth.
Catalog record
| CREATOR | Elizeth Lopes, Gisela Machado-Oliveira, Catarina Guerreiro Simões, Inês S Ferreira, Cristiano Ramos, José Ramalho, Maria I L Soares, Teresa M V D Pinho e Melo, Rosa Puertollano, André R A Marques, Otília V Vieira, Raj Kishore |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |