Myostatin and the Heart
Małgorzata Knapp, Elżbieta Supruniuk, Jan Górski, Stanislovas S Jankauskas · 2023
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Description
Małgorzata Knapp and colleagues reviewed in 2023 what myostatin, a protein best known for limiting muscle growth, does to the heart. Myostatin is secreted mainly by skeletal muscle, with smaller amounts from heart muscle and fat. It switches on signaling pathways that restrain growth. Animal studies show the heart shrinks when myostatin is overproduced and enlarges when the protein is removed.
The review gathers evidence on myostatin's diagnostic and prognostic value across heart conditions. It discusses how myostatin-null mice develop larger ventricular chambers and volumes, and how the heart may release myostatin as a brake on its own growth signals. For clinicians, a circulating factor linking skeletal muscle and heart size could become a blood marker of disease or a drug target. The authors weigh that promise against what is still unknown.
Catalog record
| CREATOR | Małgorzata Knapp, Elżbieta Supruniuk, Jan Górski, Stanislovas S Jankauskas |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |