Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling
Marit Brynjulvsen, Elise Solli, Maria Walewska, Manuela Zucknick, Luna Djirackor, Iver A. Langmoen, Awais Ahmad Mughal, Erlend Skaga, Einar O. Vik-Mo, Cecilie J. Sandberg · 2023
Read Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling by Marit Brynjulvsen, Elise Solli, Maria Walewska, Manuela Zucknick, Luna Djirackor, Iver A. Langmoen, Awais Ahmad Mughal, Erlend Skaga, Einar O. Vik-Mo, Cecilie J. Sandberg (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741477.txt.
Description
The deadliest brain tumor is not one thing but a crowd, and its stem-like cells drive its return. Marit Brynjulvsen and nine co-authors grew such cells in 2023 from seven spots across one tumor, to see how much the crowd shifts within a single mass. The seven lines looked alike in growth and broad gene use. Their gene faults and drug weak spots, though, split in real ways.
Each line faced one hundred fifteen cancer drugs, and no two lines answered quite the same. Still, the spread inside one tumor stayed below the spread between tumors from other folk. A drug screen built on one bite of tumor will thus miss part of the crowd it must kill. The team urge screens that sample the whole mass, so cures are picked against the full foe.
Catalog record
| CREATOR | Marit Brynjulvsen, Elise Solli, Maria Walewska, Manuela Zucknick, Luna Djirackor, Iver A. Langmoen, Awais Ahmad Mughal, Erlend Skaga, Einar O. Vik-Mo, Cecilie J. Sandberg |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |