Membrane Proteins and Membrane Curvature: Mutual Interactions and a Perspective on Disease Treatments
Peng Xie, Heng Zhang, Yatong Qin, Hehe Xiong, Changrong Shi, Zijian Zhou, Vladimir N Uversky, Frank Krause, Jesús Pérez-Gil · 2023
Read Membrane Proteins and Membrane Curvature: Mutual Interactions and a Perspective on Disease Treatments by Peng Xie, Heng Zhang, Yatong Qin, Hehe Xiong, Changrong Shi, Zijian Zhou, Vladimir N Uversky, Frank Krause, Jesús Pérez-Gil (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741411.txt.
Description
Peng Xie and co-authors review, in a 2023 paper, the two way relationship between cell membrane proteins and the bending of the membrane itself. Membranes are not flat sheets; their curvature shapes how cells divide, move, and take in material. Proteins can sense bends, cause bends, and be changed by them in return.
Many diseases involve this interplay gone wrong, the authors argue. The review first introduces membrane curvature and its links to membrane proteins. It then works through how the interaction plays out in disease, and what that implies for treatment. Drug strategies might target the protein, the curvature, or their coupling. The closing part weighs prospects and hurdles for turning this knowledge into therapy. The authors aim to give drug designers a fresh angle on diseases that resist current approaches.
Catalog record
| CREATOR | Peng Xie, Heng Zhang, Yatong Qin, Hehe Xiong, Changrong Shi, Zijian Zhou, Vladimir N Uversky, Frank Krause, Jesús Pérez-Gil |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |