Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response
Alexia Kim, Mauricio A. Downer, Charlotte E. Berry, Caleb Valencia, Alex Z. Fazilat, Michelle Griffin · 2023
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Description
Alexia Kim and co-authors survey biomaterials that calm the body's attack on implants. Implanted materials promise healing, yet rejection often causes more harm than the cure. Attack macrophages and scar-building cells team up in a destructive loop. The result is chronic inflammation wrapped in excess scar tissue.
Recent designs tune surface and material traits to steer immune cells instead. Some changes speak to cells directly, others reshape the local tissue setting. Anti-inflammatory and pro-regrowth signals get built into the material itself. The review maps which tweaks show real promise in studies. Harmony with the host immune system is the design goal throughout.
Catalog record
| CREATOR | Alexia Kim, Mauricio A. Downer, Charlotte E. Berry, Caleb Valencia, Alex Z. Fazilat, Michelle Griffin |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |