Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review
Kyle J. Burghardt, Megan Kajy, Kristen M. Ward, Paul R. Burghardt · 2023
Read Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review by Kyle J. Burghardt, Megan Kajy, Kristen M. Ward, Paul R. Burghardt (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10741000.txt.
Description
Kyle Burghardt and co-authors review what body chemistry reveals about antipsychotic drugs in a 2023 systematic review. These drugs anchor treatment for many mental illnesses, yet picking the right one stays trial and error. Metabolomics, the study of small molecules in a blood sample, may flag who will respond well or suffer harm.
Forty-two human studies met the review's bar, nearly all using blood plasma or serum. Fourteen metabolite classes and twelve lipid classes appeared across the work. Some shifts recurred: certain membrane lipids rose, while carboxylic acids and acylcarnitines fell in treated patients. A fall in aspartate was the most repeated single finding. The authors caution that studies differed widely in design, drug detail, and sample handling, so firm clinical rules must wait for tighter work.
Catalog record
| CREATOR | Kyle J. Burghardt, Megan Kajy, Kristen M. Ward, Paul R. Burghardt |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |