Establishment of a Spontaneous Liver Fibrosis Model in NOD/SCID Mice Induced by Natural Aging
Lihua Qiu, Zhaoxia Ma, Jianxiu Sun, Zhen Wu, Mengting Wang, Sitao Wang, Yunhui Zhao, Shu Liang, Min Hu, Yanjiao Li, Tomas Majtan · 2023
Read Establishment of a Spontaneous Liver Fibrosis Model in NOD/SCID Mice Induced by Natural Aging by Lihua Qiu, Zhaoxia Ma, Jianxiu Sun, Zhen Wu, Mengting Wang, Sitao Wang, Yunhui Zhao, Shu Liang, Min Hu, Yanjiao Li, Tomas Majtan (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10740877.txt.
Description
Lihua Qiu and co-authors show that plain aging can scar mouse livers, giving a natural model of fibrosis. Their 2023 paper notes that lab-made models often miss how the disease grows on its own with age. They compared young, middle-aged, and old mice of an immune-weak strain. Old livers at 43 weeks held many fibrous bands and much collagen.
Markers of scar-driving change ran high in the old group. Aging signs rose too, while two protective proteins fell. Under the microscope, power units in liver cells worked poorly, and antioxidant defense shrank. A known scar pathway switched on, with liver inflammation beside it. The authors offer the aged mouse as a faithful model and a first map of how age drives the scarring.
Catalog record
| CREATOR | Lihua Qiu, Zhaoxia Ma, Jianxiu Sun, Zhen Wu, Mengting Wang, Sitao Wang, Yunhui Zhao, Shu Liang, Min Hu, Yanjiao Li, Tomas Majtan |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |