Proteome Profiling of Brain Vessels in a Mouse Model of Cerebrovascular Pathology
Arsalan S. Haqqani, Zainab Mianoor, Alexandra T. Star, Flavie E. Detcheverry, Christie E. Delaney, Danica B. Stanimirovic, Edith Hamel, AmanPreet Badhwar · 2023
Read Proteome Profiling of Brain Vessels in a Mouse Model of Cerebrovascular Pathology by Arsalan S. Haqqani, Zainab Mianoor, Alexandra T. Star, Flavie E. Detcheverry, Christie E. Delaney, Danica B. Stanimirovic, Edith Hamel, AmanPreet Badhwar (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10740654.txt.
Description
Arsalan Haqqani and co-authors profile proteins in brain vessels in a 2023 mouse study. A signaling family gone wrong in vessel walls tracks with several age related dementias. Mice bred to overproduce one such signal in the brain mimic vessel disease and lose cognitive ground with age. The team pulled arteries from the brains of these mice and healthy peers at six months.
Mass spectrometry counted the proteins in each vessel sample. The census shows which vessel proteins shift as the disease pattern sets in. Such shifts may mark early vessel damage long before memory fails. They also hint at drug targets in the vessel wall itself, a site standard dementia work often skips.
Catalog record
| CREATOR | Arsalan S. Haqqani, Zainab Mianoor, Alexandra T. Star, Flavie E. Detcheverry, Christie E. Delaney, Danica B. Stanimirovic, Edith Hamel, AmanPreet Badhwar |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |