Therapeutic Potential for Beta-3 Adrenoreceptor Agonists in Peripheral Arterial Disease and Diabetic Foot Ulcers
Cameron J F Evans, Sarah J Glastras, Owen Tang, Gemma A Figtree, Irene Hinterseher, Racha El Hage · 2023
Read Therapeutic Potential for Beta-3 Adrenoreceptor Agonists in Peripheral Arterial Disease and Diabetic Foot Ulcers by Cameron J F Evans, Sarah J Glastras, Owen Tang, Gemma A Figtree, Irene Hinterseher, Racha El Hage (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10740412.txt.
Description
A bladder drug already on pharmacy shelves might be rerouted to save legs and feet. Cameron Evans and co-authors review in 2023 the case for beta-3 adrenoreceptor agonists, like mirabegron, against peripheral arterial disease and diabetic foot ulcers.
Both diseases grow from oxidative stress, where harmful oxygen species overwhelm the vessel's calming nitric oxide signal and the enzyme making it falls out of tune. Stimulating the beta-3 receptor retunes that enzyme, restoring nitric oxide, relaxing vessel walls, and coaxing new vessel growth. In theory that repairs blood flow in narrowed arteries and feeds starved ulcer tissue. The review tallies the heavy costs of the two diseases and argues the repurposing case deserves trials.
Catalog record
| CREATOR | Cameron J F Evans, Sarah J Glastras, Owen Tang, Gemma A Figtree, Irene Hinterseher, Racha El Hage |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |