Layer-by-Layer Coatings of Collagen–Hyaluronic acid Loaded with an Antibacterial Manuka Honey Bioactive Compound to Fight Metallic Implant Infections
Anjaneyulu Udduttula, Nicholas Jakubovics, Imran Khan, Lucia Pontiroli, Kenneth S. Rankin, Piergiorgio Gentile, Ana M. Ferreira · 2023
Read Layer-by-Layer Coatings of Collagen–Hyaluronic acid Loaded with an Antibacterial Manuka Honey Bioactive Compound to Fight Metallic Implant Infections by Anjaneyulu Udduttula, Nicholas Jakubovics, Imran Khan, Lucia Pontiroli, Kenneth S. Rankin, Piergiorgio Gentile, Ana M. Ferreira (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10739588.txt.
Description
Anjaneyulu Udduttula and six co-authors coat metal implants with a honey-derived layer to fight the infections that can doom the implant. Their coating stacks jellyfish collagen and hyaluronic acid in thin layers on titanium alloy, copying the matrix that surrounds cells. Into the stack they load methylglyoxal, the active compound in Manuka honey.
Lab checks confirmed the layers formed as intended and released the compound slowly, over twenty-one days. Against two common bacteria, Escherichia coli and Staphylococcus epidermidis, coatings carrying the compound in their middle layers blocked growth and settling on the surface. The loaded layers did not harm fibroblast cells in culture. With bone-forming stem cells, the coatings encouraged growth and the formation of calcium nodules. The authors present the coating as a candidate that fights infection while actively supporting new bone.
Catalog record
| CREATOR | Anjaneyulu Udduttula, Nicholas Jakubovics, Imran Khan, Lucia Pontiroli, Kenneth S. Rankin, Piergiorgio Gentile, Ana M. Ferreira |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |