Hyaluronic Acid Hydrogels with Phototunable Supramolecular Cross-Linking for Spatially Controlled Lymphatic Tube Formation
Fei Fan, Bo Su, Alexander Kolodychak, Ephraim Ekwueme, Laura Alderfer, Sanjoy Saha, Matthew J. Webber, Donny Hanjaya-Putra · 2023
Read Hyaluronic Acid Hydrogels with Phototunable Supramolecular Cross-Linking for Spatially Controlled Lymphatic Tube Formation by Fei Fan, Bo Su, Alexander Kolodychak, Ephraim Ekwueme, Laura Alderfer, Sanjoy Saha, Matthew J. Webber, Donny Hanjaya-Putra (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10739586.txt.
Description
Lymphatic vessels grow in a soft matrix whose stiffness changes over time, and those changes shape how the vessels form. Fei Fan and co-authors built a gel in 2023 whose stiffness can be tuned with ultraviolet light, in place and over time. The gel is based on hyaluronic acid, a natural component of body tissue, with links that shift from a loose form to a fixed form under light.
Human lymphatic cells grown on the softer, shifting gel formed cord-like vessel structures more readily than on stiff gels. Key lymph vessel markers rose, and the cells responded more strongly to a growth signal. The authors offer the gel as a tool for studying lymph growth and for tissue engineering.
Catalog record
| CREATOR | Fei Fan, Bo Su, Alexander Kolodychak, Ephraim Ekwueme, Laura Alderfer, Sanjoy Saha, Matthew J. Webber, Donny Hanjaya-Putra |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |