A Versatile Isocyanate-Mediated Strategy for Appending Chemical Tags onto Drug-Like Small Molecules
Catherine · 2023
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Description
The authors describe a fast way to tag drug-like molecules in a 2023 paper on probe building. To learn what a small molecule touches inside a cell, chemists must first bolt a tag onto it, and that tailoring is slow and one-off, a known bottleneck in drug hunting.
Their method uses a resin armed with a grabber group that catches the molecule, holds it at a strict one-to-one ratio, and lets it go with the tag attached. It worked on amines, thiols, phenols, and alcohols. Computer checks predict it fits more than a quarter of lead-like compounds in public libraries. As a proof, the team built light-activated probes of varied grip strength that labeled their target protein in tests.
Catalog record
| CREATOR | Catherine |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |