Adansonia digitata L. Stem Bark Attenuates Epileptic Seizure, Depression, and Neurodegeneration by Mediating GABA and Glutamate in Pentylenetetrazol-Kindled Rats
Adamu Muhammad, Luteino Lorna Hamman, Samaila Musa Chiroma, Martha Orendu Oche Attah, Nathan Isaac Dibal · 2023
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Description
Adamu Muhammad and co-authors test an extract of baobab stem bark in rats with epilepsy-like kindling. Their 2023 study asks whether the extract can ease seizures, depression, and brain damage tied to the condition.
Thirty-five rats were split into five groups. Some got saline or a seizure-inducing drug alone, others got one of two extract doses, and one group got diazepam as a standard drug. Treatment ran for twenty-six days. The team scored seizures and tested cognition and depression-like behavior. Levels of GABA and glutamate, two key brain transmitters, were also measured, since the extract is thought to act through them.
Catalog record
| CREATOR | Adamu Muhammad, Luteino Lorna Hamman, Samaila Musa Chiroma, Martha Orendu Oche Attah, Nathan Isaac Dibal |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |