High‐mobility group box 1 emerges as a therapeutic target for asthma
Qianni Yang, Min Li, Yunjiao Hou, Huilin He, Shibo Sun · 2023
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Description
Qianni Yang and four co-authors review the case for a protein called HMGB1 as a drug target in asthma. Inside the cell nucleus the protein helps run everyday jobs such as copying and repairing DNA. Escaped outside the cell, it turns into an alarm signal that stirs inflammation and immune responses. It works through several receptors and switches on a web of pathways, many of which end in more inflammation.
In asthma, those same pathways drive airway swelling and reactivity, and the review traces how HMGB1 feeds them through at least four named routes. Blocking the protein, or its partners, could in principle cut the signal at a shared upstream point. The authors conclude that HMGB1 has emerged as a genuine therapeutic target, while the hard work of turning that insight into a safe drug remains.
Catalog record
| CREATOR | Qianni Yang, Min Li, Yunjiao Hou, Huilin He, Shibo Sun |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |