CIRCADIAN CLOCK DISRUPTION: SEX-SPECIFIC EFFECTS ON METABOLISM & COGNITION IN AN ALZHEIMER’S MODEL
Laila Scroggins, Qing Zhang, Kevin Koronowski, Juan Palavicini · 2023
Read CIRCADIAN CLOCK DISRUPTION: SEX-SPECIFIC EFFECTS ON METABOLISM & COGNITION IN AN ALZHEIMER’S MODEL by Laila Scroggins, Qing Zhang, Kevin Koronowski, Juan Palavicini (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10738997.txt.
Description
Laila Scroggins, Qing Zhang, Kevin Koronowski, and Juan Palavicini report a 2023 study on broken body clocks and Alzheimer's disease. The team used a new mouse model that carries a human form of the tau protein. Half the mice lived under a steady light schedule, while the rest faced a shifting schedule like chronic jet lag.
The shifting schedule changed how the mice used fuel during fasting, with males hit harder than females. Males also gained fat mass and lost ground on a maze test of spatial memory. Females seemed shielded from the memory harm. The work links daily rhythm loss to sex-specific changes in body and brain.
Catalog record
| CREATOR | Laila Scroggins, Qing Zhang, Kevin Koronowski, Juan Palavicini |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |