A MENDELIAN RANDOMIZATION STUDY SUPPORTS CAUSAL EFFECT OF OVERWEIGHT ON LONGEVITY
Hongzhe Duan, Rachel Holmes, Konstantin Arbeev, Olivia Bagley, Deqing Wu, Anatoliy Yashin, Svetlana Ukraintseva · 2023
Read A MENDELIAN RANDOMIZATION STUDY SUPPORTS CAUSAL EFFECT OF OVERWEIGHT ON LONGEVITY by Hongzhe Duan, Rachel Holmes, Konstantin Arbeev, Olivia Bagley, Deqing Wu, Anatoliy Yashin, Svetlana Ukraintseva (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10738945.txt.
Description
Hongzhe Duan and a team of co-authors use genetics to test the obesity paradox: the claim that extra weight helps older people live longer. Their study appeared in twenty twenty-three. Plain observation links overweight with better survival, but cause and effect stay murky.
Their method, Mendelian randomization, uses gene variants as natural experiments. Few single variants pass its strict tests, so the team paired variants across eight obesity-linked genes to build many more tools. In a large United States aging study, being overweight at ages seventy-five to eighty-five raised the odds of reaching eighty-five. The effect held in both sexes and in the racial groups tested. Bigger energy reserves aiding resilience is one proposed reason.
Catalog record
| CREATOR | Hongzhe Duan, Rachel Holmes, Konstantin Arbeev, Olivia Bagley, Deqing Wu, Anatoliy Yashin, Svetlana Ukraintseva |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |