INVESTIGATING THE IMPACTS OF METFORMIN ON AGING AND LIFESPAN IN DIVERSITY OUTBRED MICE
Rong Yuan, Yun Zhu, Monica Frungieri, Michal Masternak, Andrzej Bartke · 2023
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Description
Rong Yuan and co-authors test how metformin affects aging and lifespan in mice bred for genetic variety. Metformin treats type two diabetes and acts on pathways tied to growth and cell cleanup. Whether it can slow aging or extend life is still an open question, and past work hints that genes and sex shape the answer.
Their 2023 study uses diversity outbred mice, bred from eight strains to mimic human genetic variety. Mice ate food with or without metformin from two months of age. Treated males gained weight by one year, while females did not. Breathing measures rose in both sexes, and glucose tolerance worsened in treated females, a surprise the team reports in full.
Catalog record
| CREATOR | Rong Yuan, Yun Zhu, Monica Frungieri, Michal Masternak, Andrzej Bartke |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |