DIGITAL CLOCK DRAWING PERFORMANCE ASSOCIATIONS WITH ALZHEIMER’S DISEASE GENETIC RISK SCORE AND APOE IN OLDER ADULTS
Louisa Thompson, Michael Cummings, Sheina Emrani, David Libon, Alvin Ang, Cody Karjadi, Rhoda Au, Chunyu Liu Chunyu Liu · 2023
Read DIGITAL CLOCK DRAWING PERFORMANCE ASSOCIATIONS WITH ALZHEIMER’S DISEASE GENETIC RISK SCORE AND APOE IN OLDER ADULTS by Louisa Thompson, Michael Cummings, Sheina Emrani, David Libon, Alvin Ang, Cody Karjadi, Rhoda Au, Chunyu Liu Chunyu Liu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10738663.txt.
Description
Louisa Thompson and co-authors link digital clock drawing performance with genetic risk for Alzheimer's disease in older adults. Their 2023 paper deals with early detection, since most patients are diagnosed only after symptoms appear.
A digitized clock drawing task offers a cheap, non-invasive candidate biomarker. Data came from the Framingham Heart Study, the largest such dataset to date. Nearly twenty-four hundred adults aged sixty to ninety-four had task scores. Two genetic measures were tested: carrying the APOE risk variant, and a polygenic risk score summing many variants. Associations with the composite drawing score were examined. Genetic risk may show up in pencil strokes years before diagnosis.
Catalog record
| CREATOR | Louisa Thompson, Michael Cummings, Sheina Emrani, David Libon, Alvin Ang, Cody Karjadi, Rhoda Au, Chunyu Liu Chunyu Liu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |