TRANSCRIPTOMIC ANALYSIS OF PROGERIA MODEL, KLOTHO KO MOUSE AND THE THERAPEUTIC EFFECT OF MITOCHONIC ACID 5
Yoshiyasu Tongu, Tomoko Kasahara, Takaaki Abe · 2023
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Description
Yoshiyasu Tongu, Tomoko Kasahara, and Takaaki Abe study a mouse model of fast aging and a drug that targets cell power plants, in a 2023 paper. The mice lack a protein called Klotho, which is linked to long life. Without it, they age fast and die by about ten weeks. The protein is made mainly in the kidney and brain.
The drug, called MA-5, reaches the brain and is in early human trials. Mice got the drug by mouth from four to seven weeks of age. Kidney waste markers were high in the untreated mice. Treatment shifted gene activity and eased some markers. The study reads the full gene pattern to judge how the drug acts on aging signs.
Catalog record
| CREATOR | Yoshiyasu Tongu, Tomoko Kasahara, Takaaki Abe |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |