KYNURENINE METABOLITES INDUCE MICROGLIAL CELL SENESCENCE AND STIMULATE NEUROINFLAMMATION
Jimeace Bonaparte, Maxwell Cook, Steven Dixon, Cynthia Wright, William Hill, Gavin Wang · 2023
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Description
Bonaparte, Wang and their co-authors test how kynurenine compounds affect brain immune cells in 2023. Aging raises swelling in the brain and turns on a pathway that makes these compounds, which are higher in Alzheimer disease.
The team treated human microglial cells with several compounds from the pathway at varied doses and times. One compound strongly raised markers of cell aging, while the base compound had a weak effect. That same compound also drove the strongest release of an inflammatory signal. The authors suggest these compounds may help drive brain aging and swelling linked to disease.
Catalog record
| CREATOR | Jimeace Bonaparte, Maxwell Cook, Steven Dixon, Cynthia Wright, William Hill, Gavin Wang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |