NEAR-INFRARED SPECTROSCOPY IN VIVO DISTINGUISHES AMYLOID DEPOSITION IN SUBJECTS WITH ALZHEIMER’S DISEASE
Brent Schell, Frank Greco · 2023
Read NEAR-INFRARED SPECTROSCOPY IN VIVO DISTINGUISHES AMYLOID DEPOSITION IN SUBJECTS WITH ALZHEIMER’S DISEASE by Brent Schell, Frank Greco (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10738425.txt.
Description
Brent Schell and Frank Greco test whether near-infrared light can reveal amyloid buildup in the living brain in a paper from 2023. Amyloid deposits in brain blood vessels often accompany Alzheimer's disease. Earlier work showed the light method separates patients from healthy controls. The open question was which spectral features track the deposits themselves. The team scanned twenty-six patients whose diagnoses were confirmed at autopsy.
Each brain was graded for vessel amyloid after death. Two narrow wavelength bands separated high-grade from minimal cases correctly. The authors infer those bands respond to the amyloid peptide itself. They suggest the method could track disease burden and response to new antibody therapies. More validation is still needed.
Catalog record
| CREATOR | Brent Schell, Frank Greco |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |