BIOLOGICAL AGING AND APOE STATUS REWIRE INTER-OMIC ASSOCIATIONS RELATED TO BIOENERGETICS IN HUMANS
Noa Rappaport, Dylan Ellis, Kengo Watanabe, Tomasz Wilmanski, Leroy Hood, Nathan Price, Cory Funk, Priyanka Baloni · 2023
Read BIOLOGICAL AGING AND APOE STATUS REWIRE INTER-OMIC ASSOCIATIONS RELATED TO BIOENERGETICS IN HUMANS by Noa Rappaport, Dylan Ellis, Kengo Watanabe, Tomasz Wilmanski, Leroy Hood, Nathan Price, Cory Funk, Priyanka Baloni (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10738174.txt.
Description
Noa Rappaport and co-authors show how aging and a key Alzheimer's gene variant rewire links among body chemistry measures, in this 2023 paper. The APOE gene's variants are among the strongest predictors of long life or the disease. How they act on energy pathways stayed fuzzy.
Nearly two thousand undiagnosed adults gave multi-layer molecular data. Certain fat molecules rose in carriers of both the protective and the risky variant, compared with the common form. Older biological age and the protective variant in men both tied insulin resistance more tightly to energy metabolites. A twin cohort checked the pattern. The atlas points at energy handling as APOE's lever.
Catalog record
| CREATOR | Noa Rappaport, Dylan Ellis, Kengo Watanabe, Tomasz Wilmanski, Leroy Hood, Nathan Price, Cory Funk, Priyanka Baloni |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |