GENOMIC ARCHITECTURE OF FEMALE REPRODUCTIVE AGING
Anna Murray · 2023
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Description
Anna Murray presents a 2023 paper on the genetics of female reproductive aging. A woman's store of eggs declines over life, and the timing of menopause varies widely between women. Murray's research program uses genome-wide studies to find the genes and body processes that set that timing.
Combining data from more than 200,000 women, the work found 290 gene regions tied to menopause age, jointly explaining about 12 percent of the variation. Women with the highest genetic risk were about five times more likely to reach menopause before age 40. Studies of rarer gene faults in UK Biobank data added nine more genes, one shifting menopause by over five years. The findings matter for fertility, cancer, diabetes, and bone health.
Catalog record
| CREATOR | Anna Murray |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |