METHYLATION RISK SCORES ARE ASSOCIATED WITH CARDIOVASCULAR RISK FACTORS IN OLDER US ADULTS
Lisha Lin, Wei Zhao, Kira Birditt, Jennifer Smith · 2023
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Description
Lisha Lin and co-authors test blood methylation scores against heart risk factors in older adults, in work from 2023. Methylation marks on DNA can be summed into risk scores for traits like blood pressure. Whether those scores behave the same across ages and habits was unclear.
Scores were built for eight risk factors from past genome-wide studies. Blood data came from nearly four thousand participants in a national aging study, mean age near seventy. Each score tracked its matching risk factor strongly after adjustments. Some links shifted with age, gender, or alcohol use, though. Body mass links grew steeper where scores ran high. The scores may aid early prevention if further validated.
Catalog record
| CREATOR | Lisha Lin, Wei Zhao, Kira Birditt, Jennifer Smith |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |