MICROBIOME MODULATORS IN THE PREVENTION AND MITIGATION OF CANCER TREATMENT-INDUCED ACCELERATED AGING BIOLOGY
Brandi Miller, Sidharth Mishra, Diptaraj Chaudhari, Hariom Yadav, Shalini Jain · 2023
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Description
Brandi Miller and four co-authors study gut germ helpers against the aging-like harm of cancer drugs, in a 2023 paper. Chemo saves lives but wears many organs and can speed the body's aging, in part by throwing gut germs off balance and stoking swelling. The team screened their own banked human gut strains, live and heat-killed, for anti-aging power in worms and mice.
Two strains stood out. In mice on a common chemo drug, they guarded body weight, kept gut germ mixes steady, spared the gut wall, and shielded thinking. A planned trial in cancer survivors will first map gut, leak, and swelling marks, then test the pair's safety and effect on thinking over sixty days. The work frames gut care as a shield for survivors.
Catalog record
| CREATOR | Brandi Miller, Sidharth Mishra, Diptaraj Chaudhari, Hariom Yadav, Shalini Jain |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |