DEVELOPMENT OF MITOPHAGY-INDUCING SMALL MOLECULES AS THERAPEUTICS FOR AGING AND ALZHEIMER’S DISEASE
Julie Andersen · 2023
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Description
Julie Andersen develops drugs that push cells to clear out worn mitochondria, in a 2023 paper. Faulty mitochondria build up with age as the clearing process, mitophagy, slows. Alzheimer disease, the top cause of dementia after sixty-five, may be fed by that buildup.
One known booster, urolithin A, has protected mouse brains in several Alzheimer models. Andersen's lab screened for more and found a related compound. Both compounds improved mitochondrial function in worms, shielded nerve cells in disease models, and lengthened the worms' lives. The work treats aging itself as the shared root of many diseases, rather than fighting each alone. Early human interest in the first compound gives the second a clear path to test.
Catalog record
| CREATOR | Julie Andersen |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |