PROTECTIVE EFFECT OF SHINGLES VACCINE ON ALZHEIMER’S DISEASE CAN BE MODULATED BY RISK VARIANT OF NECTIN2 GENE
Svetlana Ukraintseva, Hongzhe Duan, Rachel Holmes, Deqing Wu, Igor Akushevich, Arseniy Yashkin, Konstantin Arbeev, Anatoliy Yashin · 2023
Read PROTECTIVE EFFECT OF SHINGLES VACCINE ON ALZHEIMER’S DISEASE CAN BE MODULATED BY RISK VARIANT OF NECTIN2 GENE by Svetlana Ukraintseva, Hongzhe Duan, Rachel Holmes, Deqing Wu, Igor Akushevich, Arseniy Yashkin, Konstantin Arbeev, Anatoliy Yashin (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10736522.txt.
Description
Svetlana Ukraintseva and co-authors ask whether the shingles vaccine guards against Alzheimer's disease, and whether a risk gene changes the answer. Vaccines may brace the aging immune system in ways that reach beyond their target disease. Their 2023 paper uses the Health and Retirement Study to compare vaccinated and unvaccinated older adults, split by a variant in the NECTIN2 gene.
The team looked at vaccination between ages 65 and 75 against Alzheimer's onset after 75, adjusting for sex, race, schooling, and smoking. Overall, vaccinated people had about half the odds of later Alzheimer's. The protection concentrated in carriers of the gene's risk variant, where odds fell further still, while non-carriers showed no clear benefit. The authors conclude that off-target vaccine gains may depend on a person's genes, a twist for both dementia prevention and vaccine policy.
Catalog record
| CREATOR | Svetlana Ukraintseva, Hongzhe Duan, Rachel Holmes, Deqing Wu, Igor Akushevich, Arseniy Yashkin, Konstantin Arbeev, Anatoliy Yashin |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |