COMBINED USE OF NOVEL MR IMAGING AND FLUID BIOMARKERS REVEAL DETERMINANTS OF MYELIN AND AXONAL LOSS WITH AGING
Keenan Walker · 2023
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Description
Keenan Walker reports in 2023 on blood markers that track the loss of myelin and axons in the aging brain. White matter damage marks Alzheimer disease and other dementias, yet its molecular drivers are murky. Data came from two long-running aging studies, with blood assays for a handful of targeted proteins and a platform reading some seven thousand more.
Scans supplied measures of myelin content and axon density. Higher levels of a glial marker, GFAP, tied to lower myelin in temporal regions, and two markers tied to lower axon density overall. A set of 155 proteins linked to myelin fed a machine learning predictor the team plans to test in multiple sclerosis.
Catalog record
| CREATOR | Keenan Walker |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |