SEROTONIN AND DOPAMINE CIRCUITS MODULATE AGING IN RESPONSE TO FOOD CUES AND AVAILABILITY
Scott Leiser · 2023
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Description
Scott Leiser shows how food cues steer aging through two brain circuits in work dated 2023. Eating less is the best-known life-extending trick, but food smells can undo it. A gene switch in worm gut glows under food limits and dims near tasty food smells. Leiser screened for compounds that block the smell effect.
Three blockers turned up, and they act on serotonin and dopamine paths. Those paths, the data show, cap lifespan when food cues are near. The team mapped the neurons, receptors, and signals in play. Parts of the paths match in flies, which hints at broad reach.
Catalog record
| CREATOR | Scott Leiser |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |