NOVEL MOLECULAR MECHANISMS UNDERLYING THE ASSOCIATION BETWEEN PLCG2, ALZHEIMER’S DISEASE, AND LONGEVITY
Juan Palavicini, Juliet Garcia Rogers, Henry Miller, Susan Weintraub, Sarah Hopp · 2023
Read NOVEL MOLECULAR MECHANISMS UNDERLYING THE ASSOCIATION BETWEEN PLCG2, ALZHEIMER’S DISEASE, AND LONGEVITY by Juan Palavicini, Juliet Garcia Rogers, Henry Miller, Susan Weintraub, Sarah Hopp (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10735349.txt.
Description
Juan Palavicini and co-authors probe a gene tied to Alzheimer's risk and longevity in a 2023 study. Variants of the gene PLCG2 raise or lower disease risk by version. The gene acts mainly in microglia, the brain's immune cells. Its enzyme splits a membrane lipid into two messengers.
Brains of knockout, carrier, and normal mice were compared at three months. Lipid profiling showed sex-specific shifts in messenger lipids. Myelin-rich lipids dropped surprisingly when the gene was absent. Gene expression echoed the myelin changes in a sex-specific way. Microglia reactivity eased subtly without the gene. Cell densities shifted slightly on staining. Protein pathway analysis flagged changes in females most. The results tie a risk gene to myelin maintenance. Longevity links gain a candidate mechanism from the data. Sex differences recur as a theme throughout.
Catalog record
| CREATOR | Juan Palavicini, Juliet Garcia Rogers, Henry Miller, Susan Weintraub, Sarah Hopp |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |